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Search Result

Search Results for " ht 7 "

Targets

Dopamine Receptor 5-HT Receptor Adrenergic Receptor Autophagy

16

Compounds

7

Natural Products

10

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T5858 Sertindole Lu 23-174 Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)
T22534 8-Hydroxy-DPAT hydrobromide 8-OH-DPAT hydrobromide 5-HT Receptor
8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) (8-OH-DPAT hydrobromide) is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-Hydroxy-DPAT hydrobromide has a selectivity of almost 1000 fold for a subtype...
T10170 5-HT7 agonist 1 4-[4-[(2-chlorophenyl)methyl]-1-piperazinyl]-1H-indole,4-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1H-indole,4-[4-(2-chlorobenzyl)piperazino]-1H-indole 5-HT Receptor
5-HT7 agonist 1 (4-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1H-indole) is a selective agonist of 5-HT7 (IC50 = 222.93 nM). 5-HT7 agonist 1 can be used in studies about CNS disorders.
T2395L Vortioxetine hydrobromide Vortioxetine (Lu AA21004) HBr,Vortioxetine HBr,Lu AA21004 hydrobromide 5-HT Receptor , Serotonin Transporter
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50: 15/33/3.7/19/1.6 nM).
T2283 PX-12 IV-2,PX12 Thioredoxin
PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor gr...
T39870 5-HT7R antagonist 1 free base 5-HT7R antagonist 1 free base
5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM.
T61724 SB 258741 hydrochloride
SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].
T62503 EGFR/BRAFV600E-IN-1
EGFR/BRAFV600E-IN-1 (Compound 23) is a potent dual inhibitor of EGFR (IC50: 0.08 μM) and BRAFV600E (IC50: 0.15 μM). EGFR/BRAFV600E-IN-1 exhibited anti-proliferative effects on A-549 (IC50: 1.2 μM), MCF-7 (IC50: 0.79 μM),...
T35438 (5E)-7-Oxozeaenol
(5E)-7-Oxozeaenol is a resorcylic acid lactone that has been found in the fungus MSX 63935 and has enzyme inhibitory and anticancer activities.1,2 It inhibits TGF-β-activated kinase 1 (TAK-1; IC50 = 1.3 μM).1 (5E)-7-Oxoz...
T69589 PX-316
PX-316 is a AKT inhibior. PX-316, when administered intraperitoneally to mice at 150 mg/kg, inhibits Akt activation in HT-29 human tumor xenografts up to 78% at 10 h with recovery to 34% at 48 h. PX-316 has antitumor act...
T27269 Ensaculin HCl KA 672,KA672,Ensaculin,Anseculin Hydrochloride,KA-672 HCl
Ensaculin is a NMDA antagonist and a 5HT1A agonist potentially for the treatment of Alzheimer's disease (AD). Ensaculin showed memory-enhancing effects in paradigms of passive and conditioned avoidance in both normal and...
T36318 28-Acetylbetulin
28-Acetylbetulin is a lupane triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found inM. chiapensisand has anti-inflammatory and anticancer activities.1,2It inhibits LPS-induced...
T37167 Reduced Haloperidol
Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4...
T36639 Donecopride (fumarate hydrate)
Donecopride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4E(Ki= 8.5 nM) and an inhibitor of acetylcholinesterase (AChE; IC50= 16 nM).1It is selective for AChE over butyrylcholinesterase (BChE; IC50= ...
T37114 SB 242084 dihydrochloride
SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.IC50 value: 9.0(pKi) [1]Target: 5-HT2C antagonistin vitro: SB 242...
T16780 Rodatristat KAR5417 Others
Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).
Cat No. Product Name Synonyms Targets
T6S0654 Isocorynoxeine 7-Isocorynoxeine 5-HT Receptor
1. Isocorynoxeine (7-Isocorynoxeine) shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. 2. Isocorynoxeine exhibits a significant neuroprotective effect ...
TN1727 Helichrysetin Apoptosis , HIV Protease
Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29.
T5S1607 Morusin Mulberrochromene NF-κB , Antibacterial , STAT
1. Morusin (Mulberrochromene) possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apoptosis induction. 2. Morusin possesses anti...
T5S0506 Rotundic acid Rutundic acid Apoptosis , Others , p38 MAPK , Akt , mTOR
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) c...
TN2030 P-Hydroxyphenethyl trans-ferulate 5-HT Receptor
P-Hydroxyphenethyl trans-ferulate exhibits affinity toward 5-HT(7) receptors in a competitive binding assay. P-Hydroxyphenethyl trans-ferulate can double quinone reductase specific activity in Hepa 1c1c7 cells at a level...
T81857 Marsdenoside A
Marsdenoside A (compound 7), an isolated compound from the Alocasia genus, exhibits a weak inhibitory effect on the growth of two tumor cell lines, MGC-803 and HT-29, with IC50 values exceeding 50 μg/mL.
TN3870 Iriflophenone 2-O-Rhamnoside Dimethylmatairesinol Others
Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against t...

Natural Products

Isocorynoxeine
T6S0654
Synonym: 7-Isocorynoxeine
Target: 5-HT Receptor
Helichrysetin
TN1727
Synonym:
Target: Apoptosis, HIV Protease
Morusin
T5S1607
Synonym: Mulberrochromene
Target: NF-κB, Antibacterial, STAT
Rotundic acid
T5S0506
Synonym: Rutundic acid
Target: Apoptosis, Others, p38 MAPK, Akt, mTOR
P-Hydroxyphenethyl trans-ferulate
TN2030
Synonym:
Target: 5-HT Receptor
Marsdenoside A
T81857
Synonym:
Target:
Iriflophenone 2-O-Rhamnoside
TN3870
Synonym: Dimethylmatairesinol
Target: Others

Recombinant Proteins

Species：
Human (8)
Mouse (2)
Expression System：
HEK293 (10)
Tag：
C-His-Avi (4)
C-hFc (2)
His (2)
His,hFc (1)
hFc (1)
Cat No. Product Name Species Expression System
TMPY-01315 EMMPRIN/CD147 Protein, Mouse, Recombinant (His & hFc) Mouse HEK293
CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence var...
TMPY-01316 EMMPRIN/CD147 Protein, Mouse, Recombinant (His) Mouse HEK293
CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence var...
TMPY-06036 FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) Human HEK293
FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another i...
TMPK-01371 IGFBP-7 Protein, Human, Recombinant (hFc) Human HEK293
IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 ...
TMPK-00828 Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc) Human HEK293
MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire...
TMPK-00395 FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differen...
TMPK-00394 FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in num...
TMPY-06035 FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) Human HEK293
FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another i...
TMPK-00392 FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) Human HEK293
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in num...
TMPK-00393 FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi) Human HEK293
Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differen...
Cat No. Product Name
L2800 Serotonin Receptor-Targeted Compound Library

268 compounds
A unique collection of 268 compounds targeting serotonin receptors for high throughput screening and high content screening;

Libraries

Serotonin Receptor-Targeted Compound Library
L2800
Compounds: 268
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